The present invention relates to a cross-neutralizing antibody comprising at least one multispecific binding site that binds to the alpha-toxin (Hla) of Staphylococcusaureus and to at least one two-component toxin, Wherein the antibody comprises at least three complementarity determining regions (CDR1 to CDR3) of the antibody heavy chain variable region (VH), wherein A) said antibody comprises: a) a CDR1 comprising or consisting of the amino acid sequence YSISSGMGWG (SEQ ID NO: 1)； And b) a CDR2 comprising or consisting of the amino acid sequence SIDQRGSTYYNPSLKS (SEQ ID NO: 2)； And c) a CDR3 comprising or consisting of the amino acid sequence ARDAGHGVDMDV (SEQ ID NO: 3)； Or B) said antibody comprises: a) a parent CDR1 comprising the amino acid sequence of SEQ ID NO: 1； And b) a parent CDR2 consisting of the amino acid sequence of SEQ ID NO: 2； And c) a parent CDR3 consisting of the amino acid sequence of SEQ ID NO: 3； Wherein said functionally active CDR variant comprises or consists of an amino acid sequence comprising at least one point mutation in said parent CDR sequence and having at least 60% sequence identity to said parent CDR sequence. The present invention is also directed to such a cross-neutralizing antibody as a functionally active variant antibody of a parent antibody comprising a VH amino acid sequence of SEQ ID NO: 20 and a multispecific binding site of a VL amino acid sequence of SEQ ID NO: 39, antibody comprises at least one point mutations in any region of the framework regions (FR) or a constant domain, or SEQ ID NO: 20 and SEQ ID NO: complementarity determining regions (CDR1 to CDR6) of any of the sequences of the 39 and 10 -8 K, preferably less than 10 <； -9 >； M.본 발명은 스타필로코커스 아우레우스(Staphylococcus aureus)의 알파-독소(Hla) 및 적어도 하나의 2-성분 독소에 결합하는 적어도 하나의 다중특이성 결합 부위를 포함하는 교차-중화 항체에 관한 것으로, 상기 항체는 항체 중쇄 가변 영역(VH)의 적어도 3개의 상보성 결정 영역(CDR1 내지 CDR3)을 포함하며, 여기에서 A) 상기 항체는 a) 아미노산 서열 YSISSGMGWG (서열번호 1)을 포함하거나 이로 이루어지는 CDR1； 및 b) 아미노산 서열 SIDQRGSTYYNPSL
