#$%^&*AU2012216267A120120906.pdf#####CANRPonbl\DCC\GRS\4S40X)2_l DOC-15/8I/Oi2 Chemokine binding activity of viral TNF receptors and related proteins Abstract Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumour necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in bloking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.
