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Purification and stabilization of pharmaceutical agents for peptides and proteins
专利权人:
マンカインド コーポレイション
发明人:
スタイナー, ソロモン エス.,ウッズ, ロドニー ジェイ.,サルナー, ジョセフ ダブリュー.,スタイナー, ソロモン エス.,ウッズ, ロドニー ジェイ.,サルナー, ジョセフ ダブリュー.
申请号:
JP2010209301
公开号:
JP5774828B2
申请日:
2010.09.17
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
A method is provided for purifying a peptide or a protein comprising: providing a peptide or protein composition containing an impurity to be removed; forming a complex of the active agent with a complexing agent thereby displacing the impurity; and, removing essentially all of the impurity from the complex. A composition is provided comprising such a purified peptide complexed with a complexing agent. Microparticles comprising monomeric or dimeric insulin complexed with a complexing agent, wherein the insulin is substantially free of zinc, may be used in medicine to deliver insulin to a patient. Also provided is a formulation for use in medicine comprising insulin complexed with a complexing agent which, when administered to a patient in an effective amount, produces a peak blood insulin concentration in the patient that simulates a normal response to eating, wherein the formulation is suitable for non-intravenous administration.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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