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Compositions and methods of making brittle-matrix particles through blister pack freezing
专利权人:
THE UNIVERSITY OF TEXAS SYSTEM;BOARD OF REGENTS
发明人:
Keith P. Johnston,Joshua Engstrom,Jasmine Rowe,Alan B. Watts,Robert O. Williams, III
申请号:
US16555165
公开号:
US10660850B2
申请日:
2019.08.29
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
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