The present disclosure provides combinations of salicylamide compounds, or pharmaceutically acceptable salts thereof, and histamine blocking agents, or pharmaceutically acceptable salts thereof, for antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.本發明提供了用於拮抗未分級肝素、低分子量肝素或肝素/低分子量肝素衍生物之水楊醯胺化合物或其藥物可用的鹽及組胺阻斷劑或其藥物可用的鹽之組合。