A method of producing hybrid seeds for annual cotton by cultivating perennially, including the steps of: 1) planting annual cotton parent strains for hybridization and identifying the natural wintering capability thereof 2) for annual cotton parent strains incapable of wintering naturally, taking a perennial cotton capable of wintering naturally as a rootstock and the annual cotton incapable of wintering naturally as a scionwood for grafting, and carrying out the perennial root culture of the obtained grafted plant for annual cotton parent strains capable of wintering naturally, directly planting the strains and carrying out the perennial root culture of seedling plants thereof, or carrying out the perennial root culture of grafted plants thereof obtained according to the above grafting method and (3) hybridizing the seedling plants and/or the grafted plants to produce seeds in the year of planting and/or grafting and period of perennial cultivation.
