The present invention provides antibodies that bind human TGF-alpha and human Epiregulin and are characterized as having high affinity, selective, and strong neutralizing properties. The antibodies are useful in the treatment of diabetic nephropathy.本發明提供結合人類TGF-α及人類表皮調節素且特徵為具有高親和力、選擇性及強中和性質之抗體。該等抗體適用於治療糖尿病性腎病變。