BURGDORF, LARS,SCHULTZ, MELANIE,ROSS, TATJANA,HODOUS, BRIAN,POTNICK, JUSTIN,SUTTON, AMANDA E.,HUCK, BAYARD R.
申请号：
ES11738631
公开号：
ES2545352T3
申请日:
2011.07.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compounds of the formula I ** Formula ** where R1 designates Ar1 or Het1, R2 designates Ar2, Het2, NH (CH2) nAr2, O (CH2) nAr2 or NH (CH2) nHet2, Ar1 designates phenyl, naphthyl or biphenyl, each one of them unsubstituted or mono-, di- or trisubstituted by Hal, A, O (CH2) pCyc, Alk, (CH2) nOH, (CH2) nOA, (CH2) nCOOH, (CH2) nCOOA, S (O ) mA, phenoxy, benzyloxy, (CH2) nNH2, (CH2) nNHA, (CH2) nNA2, [C (R3) 2] nCN, NO2, (CH2) nCONH2, (CH2) nCONHA, (CH2) nCONA2, SO2NH2, SO2NHA, SO2NA2, NHCONH2, (CH2) nNHCOA, (CH2) nNHCOAlk, NHCOCH>； = CH (CH2) pNA2, CHO, COA, SO3H, 10 O (CH2) pNH2, O (CH2) pNHCOOA, O (CH2) pNHA, O (CH2) pNA2, NH (CH2) pNH2, NH (CH2) pNHCOOA, NH (CH2) pNHA, NH (CH2) pNA2, NHCOHet3, COHet3, (CH2) nHet3 O (CH2) nHet3 and / or O (CH2) nCH (OH) (CH2), Ar2 designates phenyl, naphthyl or biphenyl, each unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH2) nOH, (CH2) nOA, O (CH2) pCyc, OAr3, benzyloxy, (CH2) nCOOH, (CH2) nCOOA, S (O) mA, (CH2) nNH2, (CH2) nNHA, (CH2) nNA2, [C (R3] nCN, NO2, CONH (CH2) pNH2, CONH (CH2) pNHA, CONH (CH2) pNA2, CONH (CH2) pOA, C ONH (CH2) pOH, (CH2) nCONH2, (CH2) nCONHA, (CH2) nCONA2, SO2NH2, SO2NHA, SO2NA2, NHCONH2, (CH2) nNHCOA, (CH2) nNHCOAlk, CHO, COA, SO3H, O (CH2) , O (CH2) pNHA, O (CH2) pNA2, CONHAr3, NHCOAr3, CONH (CH2) nHet3, NHCOHet3, COHet3, (CH2) nHet3, S (CH2) nHet3 and / or O (CH2) nHet3, Het1 designates a heterocycle mono- or bicyclic aromatic having 1 to 4 atoms of N, O and / or S, which can be unsubstituted or mono- or disubstituted by A, benzyl, Het4, OH and / or OA, Het2 designates a mono- or heterocycle bicyclic saturated, unsaturated or aromatic having 1 to 4 atoms of N, O and / or S, which can be unsubstituted or mono-, di-, tri- or tetrasubstituted by Hal, A, (CH2) nHet4, OHet4, NH (CH2) nHet4, (CH2) nCOOH, (CH2) nCOOA, phenyl, benzyl, CHO, COA, (CH2) nNH2, (CH2) nNHA, (CH2) nNA2, CN, (CH2) nOH, (CH2) nOA, (CH2) pCH (OH) (CH2) pOH, (CH2) pCH (OH) (CH2) pOA, NH (CH2) pNH2, NHSO2, NASO2A, SO2A and / o
