Processes for the preparation of (3s, 4r) -3-ethyl-4- (3h-imidazo [1,2-a] pyrrolo [2,3-e] pyrazin-8-yl) -n- (2,2 , 2-trifluoroethyl) pyrrolidine-1-carboxamide and its solid state forms
AHMAD Y. SHEIKH,AHMED A. OTHMAN,AYMAN D. ALLIAN,JAYANTHY JAYANTH,LAKSHMI BHAGAVATULA,LARS F. NORDSTROEM,MATHEW M. MULHERN,MICHAEL J. ROZEMA,MOHAMED-ESLAM F. MOHAMED,PATRICK J. MARROUM,PETER T. MAYER,T
申请号：
BR112018007677
公开号：
BR112018007677A2
申请日:
2016.10.17
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present disclosure relates to processes for preparing (3s, 4r) -3-ethyl-4- (3h-imidazo [1,2-a] pyrrolo [2,3-e] pyrazin-8-yl) -n- ( 2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, their solid-state forms and their corresponding pharmaceutical compositions, treatment methods (including rheumatoid arthritis treatment), kits, synthesis methods and process products.a presente divulgação se relaciona com processos para preparar (3s,4r)-3-etil-4-(3h-imidazo[1,2-a]pirrolo[2,3-e]pirazin-8-il)-n-(2,2,2-trifluoroetil)pirrolidina-1-carboxamida, suas formas em estado sólido e correspondentes composições farma-cêuticas, métodos de tratamento (incluindo tratamento de artrite reumatoide), kits, métodos de síntese e produtos-por-processo.
