VICKER, NIGEL,LAWRENCE, HARSHANI,ALLAN, GILLIAN,BUBERT, CHRISTIAN,FISCHER, DELPHINE,PUROHIT, ATUL,REED, MICHAEL,POTTER, BARRY
申请号：
CA2519956
公开号：
CA2519956C
申请日:
2004.03.22
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
There is provided a compound of Formula (I) wherein (I) R1 is a selected from(i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R2 is capable offorming a hydrogen bond (iii) alkylaryl group, wherein the aryl group issubstituted by other than a C1-10 group (iv) alkenylaryl group wherein thearyl group is substituted (v) alkyiheteroaryl group, wherein when heteroarylgroup comprises only C and N in the ring, the aryl group is substituted byother than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide oralkylamide wherein (a) the alkyl of the alkylamide is - CH2- or -CH2CH2-, (b)the amide is di-substituted and/or (c) the amide is substituted with at leastone of a I kyl heterocycle group, al ke nyl heterocycle group, alkylheteroarylgroup, alkenylheteroaryl group, heteroaryl group, alkylamine group,alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R, together with R3 provide the enol tautomer (a)； OR R1 togetherwith R3 form (xii) a pyrazole wherein (a) R4 is =N-0-alkyl or =N-0-H group,(b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group,alkyloxyalkyl. group, branched alkyl group, and an amide and/or (c) the 2position is substituted with a group selected from -OH and -0-hydrocarbyl(xiii) a heteroaryl ring to provide a compound of the formula (b)； (II) R2isselected from groups capable of forming a hydrogen bond, a sulphamate group, aphosphonate group, a thiophosphonate group, a sulphonate group and asulphonamide group； and (III) R3 is selected from -OH, =O, or a -C(=O)-mimetic.
