MCGONAGLE, Alison E.,JORDAN, Allan,WASZKOWYCZ, Bohdan,HUTTON, Colin,WADDELL, Ian,HITCHIN, James R.,SMITH, Kate Mary,HAMILTON, Niall M.
申请号：
SG11201704686U
公开号：
SG11201704686UA
申请日:
2015.12.11
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
