The present invention relates to a kind of containing local anesthetic existing in the form of alkali and the hot glue of topical administration is suitable for coagulate pharmaceutical composition. The composition further comprises Emulsifier EL-60 and one or more surfactants, to obtain thermogelling energy.本發明涉及一種含有以鹼性形式存在的局部麻醉劑且適用於外用給藥的熱膠凝藥物組合物。所述組合物進一步包括聚氧乙烯蓖麻油和一種或多種表面活性劑,以獲得熱膠凝性能。