VENKATESH, GOPI,BOLTRI, LUIGI,COLOMBO, ITALO,LAI, JIN-WANG,FLABIANI, FLAVIO,MAPELLI, LUIGI
申请号：
EP07814553
公开号：
EP2056792A4
申请日:
2007.08.29
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 mug/mL at pH 6.8.
