Hong Kee Kim,Kyu Ho Lee,Seok Hyun Hong,Yong-kyu Kwak,Ho Chul Shin,Hun-Teak Kim
申请号：
US15417348
公开号：
US20170196932A1
申请日:
2017.01.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing leuprolide acetate and having both immediate and sustained release properties and, more specifically, to a pharmaceutical composition in which, on the basis of the total weight of active ingredients, leuprolide as an immediate release preparation is contained in 0.001 wt % to 25 wt %； and leuprolide contained in microspheres of a sustained release preparation is contained in 75 wt % to 99.999 wt %. The pharmaceutical composition of the present invention is characterized by satisfying both a drug immediate release property so as to realize the prompt exposure to a sufficient amount of drug at the early stage for expression of medicinal effects and a drug sustained release property for four weeks or longer, and the pharmaceutical composition is effective in the prevention and treatment of sex hormone-dependent positive or malignant diseases.
