Joram Slager,Dale G. Swan,Darin DuMez,Joseph Ventura,Shannon Wadman,Joseph Schmidt McGonigle,Robert W. Hergenrother
申请号：
US14280170
公开号：
US20140336571A1
申请日:
2014.05.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate； and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent； and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.
