COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14

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专利权人:

发明人:

Nhan Tran,Nathalie Meunice,Harshil Dhruv,Hongwei Yin

申请号：

US14904363

公开号：

US20160146784A1

申请日:

2014.07.09

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.

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