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תכשיר רוקחות לשחרור מבוקר תלוי – ph עבור חומרים שאינם אופיאודיים ואשר עמידים נגד השפעת אלכוהול
专利权人:
EVONIK ROHM GMBH
发明人:
申请号:
IL20387010
公开号:
IL203870A
申请日:
2010.02.10
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0. characterized in that the coating layer further contains 110 to 250% by weight, calculated on dry weight of the polymer mixture, of a non-porous inert lubricant and the is present in an amount of at least 60% by weight calculated on the weight of core.
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