Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof

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专利权人:

ZIOPHARM ONCOLOGY INC.

发明人:

WALIGORA FRANK WALTER,AMEDIO JR JOHN C.

申请号：

NZ60380109

公开号：

NZ603801A

申请日:

2009.07.30

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Disclosed is a method for the preparation of a salt of isophosphoramide (or analog) of formula (E) comprising treating the neutral isophosphoramide (or analog) with a base under salt-forming conditions, wherein the salt-forming conditions comprise combining approximately equimolar amounts of tris(hydroxymethyl)aminomethane (also known as tris(hydroxymethyl)methylamine, Tris) and the neutral isophosphoramide (or analog).

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