Vasculature closure devices, and systems and methods for their use, are provided. In one embodiment, the vasculature closure device includes an expandable support frame deployable into a vessel through a puncture site and a sealing membrane at least partially supported by the expandable support frame. The support frame is positioned along a periphery of the sealing membrane. Upon expanding the support frame within the vessel, the support frame is configured to intraluminally push the sealing membrane against the puncture site.
