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Means for the treatment of myelofibrosis
专利权人:
НИТТО ДЕНКО КОРПОРЕЙШН (JP)
发明人:
НИИТСУ Йоширо (JP),МАТСУНАГА Такуя (JP)
申请号:
RU2011112645/15
公开号:
RU2011112645A
申请日:
2009.09.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A substance delivery vehicle for delivering a substance to a bone marrow cell producing an extracellular matrix containing a retinoid as a directing agent. ! 2. The carrier according to claim 1, where the retinoid contains retinol. ! 3. The carrier according to claim 1 or 2, where the content of the retinoid is 0.2-20 wt.% Of the total mass of the carrier. ! 4. The carrier according to claim 1 or 2, where the carrier is in the form of a liposome, and the molar ratio of retinoid to lipids contained in the liposome is 8: 1-1: 4. ! 5. A composition for treating myelofibrosis containing a drug that controls the activity or growth of an extracellular matrix bone marrow cell. ! 6. The composition according to claim 5, additionally containing a carrier according to any one of claims 1 to 4. ! 7. The composition according to claim 5 or 6, where the drug, which controls the activity or growth of bone marrow cells producing an extracellular matrix, is selected from the group consisting of a means for inhibiting the activity or production of a bioactive substance selected from the group consisting of gelatinase A , gelatinase B and angiotensinogen, an inhibitor of cell activity, a growth inhibitor, an apoptosis-inducing agent, as well as siRNA, ribozyme, antisense nucleic acid and DNA / RNA of a chimeric polynucleotide, which are Lena on at least one of the molecules forming the extracellular matrix, or molecules involved in the production or secretion of said molecules forming the extracellular matrix, and a vector that expresses said siRNA, ribozyme, antisense nucleic acid and DNA / RNA chimeric polynucleotide. ! 8. The composition according to claim 7, where the molecule involved in the production or secretion1. Доставляющий вещество носитель для доставки вещества к клетке костного мозга, продуцирующей внеклеточный матрикс, содержащий ретиноид в качестве направляющего агента. ! 2. Носитель по п.1, где ретиноид содержит ретинол. ! 3. Носитель по п.1 или 2, где содержани
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