Nigel J Liverton,Christelle Boléa,Sylvain Celanire,Yunfu Luo
申请号：
US13809579
公开号：
US20130210807A1
申请日:
2011.07.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention describes and claims compounds of the Structural Formula I, Structural Formula II, or Structural Formula III: wherein R1, R2, R3 and R3′ are —H or methyl, or R3 and R3 taken together form a double bond, or R3′ is —H and R2 and R3 taken together form a spiro-cyclopropyl substituent, R4 is —H or —F, and R5 is —H, methyl, —CI or —Br, Formula II wherein R1 is —H, ethyl-, isopropyl-, cyclopropyl-, methyl- or methoxy-, R4 is —H or —F, and “Y” is: (a) —CH2— (b) —CR6H-0-CR7R8—, wherein R6, R7, and R8 are independently —H or methyl (c) —CR6H—N(R9)—CR7R8—, wherein R6, R7, and R8 are independently —H or methyl (d) —CH2—C(R9)(R10)—C(R7)(R8)—, wherein R7, R8, R9 and R10 are independently —H or -methyl, or both R7 and R8 are —F, R9 and R10 are independently —H or -methyl, or both R9 and R10 are —F, or R9 and R10 taken together are (0=), which together with the carbon to which they are attached forms a carbonyl group.
