嘧啶基-吡啶氧基-萘基化合物以及治療IRE1相關之疾病及病症的方法农业专利-农业学术服务平台

专利权人:: GENENTECH, INC.; INC.;GENENTECH;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:: BRAUN, MARIE-GABRIELLE,布朗　玛丽－盖伯瑞,布朗　瑪麗－蓋伯瑞,GIBBONS, PAUL,吉朋斯　保罗,吉朋斯　保羅,LEE, WENDY,李　温蒂,李　溫蒂,LY, CUONG,立　邱,RUDOLPH, JOACHIM,鲁道夫　乔克姆,魯道夫　喬克姆,SCHWARZ, JACOB,史琪华兹　杰考伯,史琪華茲　傑考伯,ASHKENAZI, AVI,亚希克那夕　亚维,布朗玛丽-盖伯瑞,布朗瑪麗-蓋伯瑞,吉朋斯保罗,吉朋斯保羅,李温蒂,李溫蒂,立邱,鲁道夫乔克姆,魯道夫喬克姆,史琪华兹杰考伯,史琪華茲傑考伯,亚希克那夕亚维

摘要：: Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.本文描述了具有肌醇必需酶1 (IRE1)調節活性或功能的具有式I結構之嘧啶基-吡啶氧基-萘基化合物：或其立體異構體、互變異構體或藥學上可接受之鹽，並且具有本文所述之取代基及結構特徵。還描述了包含式I化合物之藥物組合物及藥劑，以及單獨使用此類IRE1調節劑及與其他治療劑組合使用此類IRE1調節劑的方法，該方法用於治療雌激素受體介導的或依賴於雌激素受體的疾病或病狀。