A surgical system has a jaw assembly including a plurality of fasteners, an anvil (434) and a drive beam (462) for pushing an actuation sled (440). A drive screw (460) imparts motion to the drive beam. An elongated body (200) is configured to connect with the jaw assembly. A drive link (502) connects a flexible drive shaft (119) to the drive screw, the drive link being disposed off-axis. The jaw assembly and elongated body are separable from each other.
