MENSCHLICHE PD-1-KNOCKDOWN-SIRNA, CAR-T-VEKTOR MIT REKOMBINANTER EXPRESSION, HERSTELLUNGSVERFAHREN DAFÜR UND ANWENDUNG DAVON

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专利权人:

Shanghai Unicar-therapy Bio-Medicine Technology Co.; Ltd

发明人:

QI, Wei,YU, Lei,KANG, Liqing,YU, Zhou

申请号：

EP17878422

公开号：

EP3505631A4

申请日:

2017.11.13

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/