There is provided a musculoskeletogenic ("MSG") graft composite made from whole bone marrow aspirate ("BMA") having a native level of musculoskeletal progenitor cells ("MSPCs") and a native level of red blood cells ("RBCs"), comprising: a) a physiologic fraction of BMA comprising: i) MSPCs present in the physiologic fraction at a level greater than their native level in whole BMA, and ii) RBCs derived from BMA present in the physiologic fraction at a level less than their native level in whole BMA, and b) a porous sterile matrix having an average pore size of at least 20 µm.
