Formula (i) (in formula, R1, R2, R3, as for R4 and R5, as defined in the bill, is) the new 5 the 7 amino which is substituted [1,3] chiazoro [4,5 d] with the salt which on the pyrimidine derivative and its medicine it can allow the production method, including that, the medicine composition which becomes and the use in remedying are disclosed. The chemical compound formula (i) is CX3 CR1 receptor antagonists, because of that for example nervous denaturation obstacle, the deviation from medulla disease, heart blood vessel characteristic - and the brain blood vessel characteristic ateromu muscardine, the peripheral artery disease, joint riumachi, the lung disease COPD and the asthma, or painfully in remedy or prevention is useful in profit.式(I)(式中、R1、R2、R3、R4及びR5は、明細書に定義された通りである)の新規な5-置換された7-アミノ[1,3]チアゾロ[4,5-d]ピリミジン誘導体及びその医薬上許容しうる塩と共にその製造方法、それを含んでなる医薬組成物並びに治療におけるその使用が開示されている。式(I)の化合物はCX3CR1受容体アンタゴニストであり、そのため神経変性障害、脱髄疾患、心血管性-及び脳血管性アテローム硬化症、末梢動脈疾患、関節リウマチ、肺疾患例えばCOPD、喘息、又は疼痛を治療又は予防に得に有用である。
