ХАРТ Чарльз Э. (US),ЛИНЧ Самьюэл Э. (US),ЭРЛИХ Майкл Дж. (US),МУР Дуглас К. (US)
申请号：
RU2010137106/15
公开号：
RU2010137106A
申请日:
2009.02.09
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of stimulating osteogenesis in an osteodistraction procedure, where the stimulation of osteogenesis involves: using an effective amount of a composition containing a solution of platelet growth factor (PDGF), which is in a biocompatible matrix, in the area of bone distraction,! where the PDGF solution consists of PDGF in a buffer； ! where PDGF is present in solution in a concentration that is in the range from about 0.01 mg / ml to about 10 mg / ml； ! where the biocompatible matrix: (i) consists of porous calcium phosphate, (ii) consists of collagen and porous calcium phosphate, (iii) consists of an allograft, (iv) consists of collagen and an allograft, or (v) consists of collagen,! where calcium phosphate or an allograft contains interconnected pores, and! where the calcium phosphate or allograft is composed of particles with a size in the range from about 100 microns to about 5000 microns. ! 2. The method according to claim 1, in which the composition is used in the osteodistraction procedure during the distraction phase. ! 3. The method according to claim 1, in which the composition is used in the osteodistraction procedure during the consolidation phase. ! 4. The method according to claim 1, in which the composition is used during phases and distraction and consolidation in the osteodistraction procedure. ! 5. The method according to claim 1, where the method involves accelerating the consolidation of the bone after osteodistraction. ! 6. The method according to claim 1, in which the composition is used in the osteodistraction site at least twice. ! 7. The method according to claim 1, in which the biocompatible matrix consists of porous calcium phosphate. ! 8. The method according to claim 7, in which the composition can be entered by injection. ! 9. The method according to claim 7, in which calcium phosphate contains β-TCP. ! 10. The method according to claim 7, in which the porosity of calcium phosphate1. Способ стимуляции остеогенеза в процедуре о
