Methods for modulating skeletal remodeling and patterning by modulating SHN2 activity, SHN3 activity, or SHN2 and SHN3 activity in combination

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专利权人:

Laurie H. Glimcher

发明人:

Laurie H. Glimcher,Dallas C. Jones,Marc Wein

申请号：

US13521709

公开号：

US09745589B2

申请日:

2011.01.13

申请国别(地区):

US

年份:

2017

代理人:

摘要：

This invention is based, at least in part, on the discovery that Shn2 and Shn3 play an important role in skeletal remodeling and skeletal patterning. Accordingly, the present invention provides methods for identifying medulators of Shn2 activity and methods for modulating bone formation and mineralization and Shn2-associated disorders using agents that modulate Shn2 expression and/or activity, in addition to methods for modulating Shn2 and Shn3.

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中国工程科技知识中心

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http://www.ckcest.cn/home/