A needle insertion assistance device is provided to easily hold a needle device, which comprises a syringe and a needle having a needle wing and being attached to the syringe, in order to more reliably control the advancement of the needle during insertion of the needle into a targeted part of a human body for many medical purposes. One embodiment of the needle insertion assistance device may comprise a supporting plate, a base connected hingedly to a rear surface of the supporting plate, and a syringe holder securely affixed to a top surface of the base to slidably hold the syringe on the base and prevent the syringe from moving from side to side. This embodiment of the needle insertion assistance device may further include a needle blocker, a handle, and an angle adjusting assembly.
