To inhibit production of adipocytokines, in particular,adipocytokines that elicit insulin resistance and to preventonset of pathosis caused by the insulin resistance, or improvethe pathosis, the present invention provides an agent or a foodor drink which contains3-O-.beta.-D-glucopyranosyl-4-methylergost-7-en-3-ol, or anorganic solvent extract, a hot water extract or a squeezed liquidof a plant of the family Liliaceae or a fraction thereof whichcontains the compound as an active ingredient.