LIPOXEN TECHNOLOGIES LIMITED;BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.
发明人:
SIEKMANN JUERGEN,NATH SRIJIT,DWIVEDI ARCHANA,ROTTENSTEINER HANSPETER,HAIDER STEFAN,JAIN SANJAY,GREGORIADIS GREGORY,TURECEK PETER
申请号：
NZ62381010
公开号：
NZ623810A
申请日:
2010.07.26
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a method of conjugating polysialic acid (PSA) or a modified PSA (mPSA) to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein comprising a carbohydrate group, comprising contacting the oxidized carbohydrate moiety with the PSA or mPSA under conditions that allow conjugation, wherein said PSA or mPSA contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the PSA or mPSA. Further disclosed is a conjugated glycoprotein other than a blood coagulation protein comprising: (a) the glycoprotein； and (b) at least one hydrazide-PSA or hydrazide-mPSA bound to the glycoprotein of (a), wherein said hydrazide-PSA or hydrazide-mPSA is attached to the glycoprotein via one or more carbohydrate moieties.
