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Vaccine compositions with reduced Foam Formation
专利权人:
INC.;MERIAL
发明人:
NOEL YVES HENRY JEAN GENIN
申请号:
ARP150103298
公开号:
AR102250A1
申请日:
2015.10.13
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
Claim 1, characterized in that it comprises: a process, reduce the formation of Foam of a vaccine composition of Solid when mixed with a Liquid diluent,Where the composition comprises: (i) at least one antigenic Component comprising an anhydrous susceptible to formation of Foam Stabilizer; wherein the process comprises: (a) adding an effective amount of a Sugar alcohol Composition of sound to the vaccine.Claim 5: a process according to claim 1, wherein the antigenic component is Newcastle disease virus, Infectious bronchitis virus, the Avian Smallpox virus, Avian encephalomyelitis virus, Marek's disease virus, TR Ichophyton verrucosum, Avian paramyxovirus, Mycobacterium paratuberculosis, meleagrid herpesvirus,The orf virus or the Sheep pox virus. Claim 27: a process according to claim 1, wherein the Sugar alcohol is xylitol, mannitol or sorbitol, or a mixture thereof.Claim 28: a stable vaccine composition, characterized in that it comprises: (i) at least one antigenic Component comprising an anhydrous Foaming Stabilizer susceptible when the composition is mixed with a diluent Liquid; and (ii) an effective amount of a Foam control agent which is a Sugar alcohol.Claim 54: a method of Immunization of a subject against a disease, characterized in that it comprises the steps of: (a) Dissolving the composition of claim 28 Vaccine, which provides protection against the disease, with a Solvent to form a solution; and (b) managing The resulting solution to the subject in an amount effective for immunizing a subject against the disease.Reivindicación 1: Un proceso, caracterizado porque comprende reducir la formación de espuma de una composición de vacuna sólida cuando se mezcla con un diluyente líquido, en donde la composición comprende: (i) por lo menos un componente antigénico anhidro que comprende un estabilizante susceptible a la formación de espuma; en donde el proceso comprende: (a) agregar una cantidad eficaz de un alcohol de azúcar a la composición de vacuna sólida. R
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