Disclosed herein is a blood withdrawal system (10) for withdrawing blood for diagnostic purposes, comprising: a base device configured to hold a structurally distinct lancet (20). The base device comprises an actuatable lancet ejection mechanism for ejecting the lancet from the base device, wherein the lancet ejection mechanism comprises a movable coupling element (30). The coupling element (30) comprises a coupling structure for coupling the lancet (20) with an external component (40) via the coupling element (30) and subsequently activating the lancet ejection mechanism by operating the external component (40).