Manfred Rieger;Geert C. Mudde;Friedrich Scheiflinger;Randolf Kerschbaumer;Michael Thiele;Rene Hoet;Juergen Muellberg
发明人:
Randolf Kerschbaumer,Friedrich Scheiflinger,Manfred Rieger,Michael Thiele,Geert C. Mudde,Juergen Muellberg,Rene Hoet
申请号：
US12767635
公开号：
US08668909B2
申请日:
2010.04.26
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
