#$%^&*AU2013204313A120131219.pdf#####-50ABSTRACT The present invention provides a pharmaceutical combination for treating a proliferative disease. The composition comprises (a) a vascular disrupting agent and (b) at least one hypoxia targeting agent. The present invention also provides a method for treating a proliferative disease including the step of administering to a patient in need thereof: a) a vascular disrupting agent and (b) at least one hypoxia targeting agent. 5068961-1