The present invention is directed to new compositions that are described for the simultaneous, controlled dose delivery of a variety of biomolecules into phagocytic cells. Such a composition is a biologically active composition comprising: (1) at least one of the following biologically active components: (a) a nucleic acid or a derivative thereof； (b) a nucleoside, nucleotide, or a derivative of a nucleoside or nucleotide； (c) a peptide, protein, or a derivative of a peptide or protein； (d) a lipopolysaccharide or a derivative thereof； (e) a peptidoglycan or a derivative thereof； (f) a carbohydrate or a derivative thereof； (g) a lipid or a derivative thereof； (h) a lipopeptide or a derivative thereof； (i) a metal ion； (j) a thiol； (k) an antibiotic or a derivative thereof； (I) a vitamin or a derivative thereof； (m) a bioflavonoid or a derivative thereof； (n) an antioxidant or a derivative thereof； (o) an immune response modifier； (p) an antibody； (q) a biologically active nonmetal； (r) histamine or an antihistamine； and (s) a kinase inhibitor； and (2) at least one carrier effective to deliver the composition to a phagocytic cell such that the biologically active component is taken up by the phagocytic cell and influences its biological activity.
