Crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl)phenyl)benzamide and its mono hydrochloride salt

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专利权人:

ARIAD PHARMACEUTICALS INC.

发明人:

Murray, Christopher,Rozamus, Leonard,Chaber, John,Sharma, Pradeep

申请号：

NZ70964813

公开号：

NZ709648A

申请日:

2013.12.12

申请国别(地区):

NZ

年份:

2020

代理人:

摘要：

Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{ 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl} benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein. The instant application is directed to a novel crystalline Form A of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{ 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl} benzamide mono hydrochloride that maintains its form under particular thermal, humidity, and pressure stresses.

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