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Compounds and compositions as protein kinase inhibitors
专利权人:
Advait Nagle;Nathanael S. Gray
发明人:
Advait Nagle,Nathanael S. Gray
申请号:
US12088649
公开号:
US08592433B2
申请日:
2006.10.20
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention provides a novel class of compounds having the structure of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Aurora-A, Axl, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKKα, IR, JNK2α2, Lck, Met, MKK6, MST2, p70S6K, PDGFRα, PKA, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, Syk, Tie2 and TrkB kinases:
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