Compounds and compositions as protein kinase inhibitors

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专利权人:

Advait Nagle;Nathanael S. Gray

发明人:

Advait Nagle,Nathanael S. Gray

申请号：

US12088649

公开号：

US08592433B2

申请日:

2006.10.20

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention provides a novel class of compounds having the structure of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Aurora-A, Axl, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKKα, IR, JNK2α2, Lck, Met, MKK6, MST2, p70S6K, PDGFRα, PKA, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, Syk, Tie2 and TrkB kinases:

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