A medical device and method for combination lung ventilation and mucus clearance of a patient is disclosed. The medical device may be configured to provide lung ventilation with intermittent, on-demand mucus clearance, freeing the patients mouth for activities of daily living such as when the patient is awake and, in another configuration, the device can provide lung ventilation with automated mucus clearance, such as when the patient is sedated or asleep. The medical device may comprise a pressure generation source, a ventilation portion, and a mucus clearance portion. The mucus clearance portion may be separable from or separate from the ventilation portion such that the medical device is capable of maintaining lung ventilation with the mouth interface removed from the patient.
