BARBARA CARNEMOLLA,CHRISTOPH-STEPHAN HILGER,ENRICA BALZA,LAURA BORSI,LUCIANO ZARDI,MATTHIAS FRIEBE,PATRIZIA CASTELLANI
申请号：
BR0308376
公开号：
BRPI0308376A2
申请日:
2003.03.11
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to selectively targeting tumoral vasculature in vivo using a human recombinant scFv, L19, to the angiogenesis marker ED-B domain of fibronectin. In preferred embodiments, a complete human IgG1 is employed having the variable regions of L19. In other embodiments is employed a mini-immunoglobulin generated by fusing the scFv L19 to the constant CH4 domain of a secretory IgE isoform that naturally contains a cysteine in its COOH terminal and which forms a covalently linked dimer. Different in vivo behaviour of the antibody formats is exploitable for different diagnostic and/or therapeutic purposes, depending on clinical needs and disease. The antibody molecules may be labelled as described.
