AMELIORATION DE L'EXPRESSION ET DU REPLIEMENT DANS LE PROCEDE DE FABRICATION DE LA PROTEINE CD-RAP GRACE A L'UTILISATION D'UNE PROTEINE PRECURSEUR DE CD-RAP
SCHOETTLE, ISABELL,STOMMES, JUDITH,STILLGER, URSULA,BARTNIK, ECKART,JESKE, VOLKER,SAAS, JOACHIM,HABERMANN, PAUL (DECEASED),JANOCHA, BERND
申请号：
CA2998665
公开号：
CA2998665A1
申请日:
2016.09.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.
