Michel Schneider,Philippe Bussat,Feng Yan,Christian Guillot
申请号：
US10544123
公开号：
US09364569B2
申请日:
2004.02.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
