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ПРОТИВООПУХОЛЕВАЯ АКТИВНОСТЬ ВОССТАНОВЛЕННЫХ ФОЛАТОВ, ТАКИХ КАК МЕТИЛЕНТЕТРАГИДРОФОЛАТ
专利权人:
ИСОФОЛ МЕДИКАЛ АБ (SE)
发明人:
ГУСТАВССОН Бенгт (SE),КАРЛССОН Бьерн (SE)
申请号:
RU2014133725
公开号:
RU2014133725A
申请日:
2013.01.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Application methylenetetrahydrofolate in treating cancer, wherein said methylenetetrahydrofolate introduced separately from other anticancer drugs sredstv.2. Application according to Claim. 1, wherein said methylenetetrahydrofolate administered as monoterapii.3. Application according to Claim. 1 or 2, wherein said methylenetetrahydrofolate is [6R] -metilentetragidrofolat.4. Applications of claim. 3, wherein said [6R] -metilentetragidrofolat has a purity of 90% or vyshe.5. Application according to Claim. 1, wherein said cancer treatment is the suppression of growth opuholi.6. Application according to Claim. 1, wherein said cancer treatment is a reduction in volume opuholi.7. Application according to Claim. 1, where methylenetetrahydrofolate, tetrahydrofolate or methyltetrahydrofolate use in treating cancer, which is a solid opuhol.8. Application according to Claim. 1, wherein said methylenetetrahydrofolate administered in an amount of at least 10 mg / m, preferably at least 20 mg / m, more preferably at least 50 mg / m, most preferably at least 100 mg / m, 200 mg / mi to 500 mg / m, and at most 5 g / M.9. Application according to Claim. 1, wherein said methylenetetrahydrofolate administered once or twice a day, every second or third day, once or twice a week or once every other ilitretyu nedelyu.10. Application according to Claim. 1, wherein said methylenetetrahydrofolate administered intravenously, orally, intraperitoneally, subcutaneously, intramuscularly, intraarterially or intranazalno.11. Application according to Claim. 1, wherein the cancer is selected from breast cancer, stomach cancer, cancer of the gastrointestinal tract, gallbladder cancer, bile duct cancer, colon cancer, rectum cancer, liver cancer, pancreatic cancer, head and neck cancer , cancer of the esophagus, the evil1. Применение метилентетрагидрофолата в лечении рака, где указанный метилентетрагидрофолат вводится отдельно от других противораковых лекарственных средств.2. Применения по п. 1, где
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