The subject invention provides use of 5,6-benzoflavone for preparing a composition for treating and/or preventing a skin disease associated with hyperseborrhea in a human being, wherein the 5,6-benzoflavone is present in the composition in an amount between 0.005% and 1% by weight of the composition and wherein the composition is topically applied. The subject invention also provides a composition comprising 5,6-benzoflavone and a pharmaceutically acceptable carrier, wherein the 5,6-benzoflavone is present at a concentration between about 0.1% and about 1% by weight and wherein the pharmaceutically acceptable carrier comprises polyethylene glycol having an average molecular weight of about 400 g/mol and ethanol.