SLEEMAN, Mark, W.,MARTIN, Joel, H.,HUANG, Tammy, T.,MACDONALD, Douglas
申请号：
LT09793408
公开号：
LT2358756T
申请日:
2009.12.15
申请国别(地区):
LT
年份:
2017
代理人:
摘要：
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
