Nancy J. Halas,Oara Neumann,Amanda M. Goodman,Sandra W. Bishnoi,Susan E. Clare
申请号：
US16595060
公开号：
US20200164072A1
申请日:
2019.10.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A nanosample capable of near-infrared light-triggered release of therapeutic molecules. The nanosample includes a plurality of nanocomplexes. Each of the nanocomplexes includes a nanoshell； a host molecule linked to the nanoshell； and a guest molecule linked to the host molecule. The nanoshell includes a shell. The nanocomplex has a plasmon resonance wavelength. When irradiated with electromagnetic radiation of the plasmon resonance wavelength, plasmon resonance of the nanocomplex releases the guest molecule. The nanoshell may also include a core, where the shell surrounds the core. The nanoshell may be a nanomatryoshka. A link between the nanoshell and the host molecule may be a gold-thiol interaction. The shell may include at least one metal, such as gold or silver. The core may be a liposome and/or silica. The host molecule may be: synthetic polymers, biopolymers, polynucleotides, nucleic acids, polypeptides, polysaccharides, polyterpenes, lipids, aptamers, and/or proteins. The guest molecule may be: pharmaceutical molecules, biopharmaceutical molecules, oligonucleotides, nucleic acids, dye molecules, and/or imaging contrast agents. The host molecule may be: aptamer, single-stranded DNA, double-stranded DNA, and/or human serum albumin. The guest molecule may be: docetaxel, lapatinib, and/or tumor necrosis factor alpha. The plasmon resonance wavelength may be in a near-infrared (NIR) water window.
