Piperazinotrizole compound, preparation method therefor, and use thereof in drug preparation

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专利权人:

Chinese Academy of Sciences;Shanghai Institute of Materia Medica

发明人:

Zhang, Ao,Miao, Zehong,Ye, Na,Huan, Xiajuan,Song, Zilan,Chen, Chuanhuizi,Chen, Yi,Ding, Jian

申请号：

AU2013299117

公开号：

AU2013299117B2

申请日:

2013.07.24

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

Provided is a piperazinotrizole compound represented by general formula I or an isomer, a pharmaceutically acceptable salt, ester, prodrug or hydrate thereof. Also provided are a method for preparing the compound, a drug composition containing the compound, and a use thereof as a high-selectivity poly(ADP-ribose) polymerase-1 (PARP1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/