Forms and Formulations of VX-950

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

MURPHY, MAURA,DINEHART, KIRK,HURTER, PATRICIA,CONNELLY, PATRICK,CUI, YONG

申请号：

NZ58847105

公开号：

NZ588471A

申请日:

2005.06.08

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed herein are solid dispersion comprising VX-950 (telaprevir) and a polymer, particularly hydroxyproplymethylcellulose (HPMC) or hydroxypropylmethylcellulose acetate succinate (HPMCAS), wherein the solid dispersion is obtained by spray drying and a polymer is present in an amount from about 10% by weight to about 80% by weight. Said forms and formulations disclosed herein have improved bioavailability relative to crystalline VX-950 and are useful for treating HCV infection.

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中国工程科技知识中心

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http://www.ckcest.cn/home/