A bone cement mixing and delivery assembly (30) is disclosed for mixing a powdered copolymer and a liquid monomer to form a bone cement and delivering the bone cement. The assembly includes a cartridge having a distal end (34) and a proximal end (36) and defining a mixing chamber (40) between the distal end and the proximal end. A transfer mechanism having a cap (52) and a stem supporting a piston (64) and a plunger is connected to the distal end. The transfer mechanism includes a first advancement mechanism (68) for advancing the piston and plunger in unison and a second advancement mechanism (70) for moving the plunger independent of the piston. The assembly further includes a removable handle (120) having a shaft for attachment of a mixing blade and a quick-release connector (142) and a release button (144) for locking and unlocking the mixing blade (128) from the removable handle.
