PREPARATION OF APHIDICOLIN AND/OR ITS DERIVATIVE

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专利权人:

ASAHI KASEI KOGYO KK

发明人:

SAKAMURA SADAO,ICHIHARA AKITAMI,OIKAWA HIDEAKI,HAYASHI KAZUKO

申请号：

JP19820100731

公开号：

JPS58220690(A)

申请日:

1982.06.14

申请国别(地区):

日本

年份:

1983

代理人:

摘要：

PURPOSE:To obtain the titled compound having an inhibitory action on the growth of plant seed, inhibiting biosynthesis of DNA, by cultivating a fungus belonging to the genus Phoma betae, forming and accumulating the titled compound, isolating and collecting it from the culture solution. CONSTITUTION:A fungus such as Phoma betae Frank PS-13 (FERM-P6556) belonging to the genus Phoma betae, is cultivated in a nutritive medium, aphidicolin shown by the formula (when R is H) and/or aphidicolin-17-monoacetate (when R is acetyl group) is formed and accumulated, and isolated from the culture solution, to give aphidicolin and/or aphidicolin-17-monoacetate having an inhibitory action on the growth of plant seed, and an action to inhibit specifically DNA biosynthesis.

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